Coronary artery spasm (CAS) plays an important role in the pathogenesis of a wide variety of ischemic heart diseases. Several case reports have shown that CAS due to hypocalcemia can mimic myocardial infarction.

We describe recurrent acute coronary syndrome in an otherwise healthy young woman without cardiac risk factors caused by coronary spasms, alternatively occurring in all three major coronary arteries.

Isolated hypocalcemia may cause acute coronary artery spasm, leading to recurrent acute coronary syndrome. This unusual cause of recurrent acute coronary syndrome occurred in a young, otherwise healthy female with no risk factors for coronary artery diseases. Medical treatment would resolve the spasm in the large majority of patients.